A large part of IEF has been modified and open sourced for KubeEdge. KubeEdge is based on Huawei’s Intelligent Edge Fabric (IEF) - a commercial IoT edge platform based on Huawei IoT PaaS. KubeEdgeĪt KubeCon+CloudNativeCon 2018 in Seattle, Huawei presented KubeEdge, the official project to bring the power of Kubernetes to the edge. K3s is bringing Kubernetes to the edge computing layer by making it accessible and lightweight. Its architecture, while maintaining full compatibility and compliance with Cloud Native Computing Foundation (CNCF) Kubernetes conformance tests, is highly optimized for unattended, remote deployments on resource-constrained devices. K3s can be deployed on the most virtual machine in the public cloud, or even on a Raspberry Pi device. It is a unified control plane that integrates seamlessly with existing tools and systems, and makes it easy to set policies, quotas and track reports. These jobs may include deploying virtual machines on physical hosts, placing containers in edge devices, or even extending the control plane to other schedulers such as serverless environments.įrom bare-metal servers to virtual machines to the internet of things (IoT) devices to managed cloud services, Kubernetes has gone beyond containers and pods to tackle multiple provisioning and scheduling challenges.īelow are a few examples of this pattern: CrossplaneĬrossplane aims to standardize infrastructure and application management using the same API-centric, declarative configuration and automation approach pioneered by Kubernetes. Kubernetes is fast becoming the preferred control plane for scheduling and managing jobs in highly-distributed environments. It can solve many of the problems that exist in traditional distributed systems. The powerful scheduler, which was originally designed to deal with the placement of pods on appropriate nodes, is quite extensible. These results demonstrate that MOF nanoparticles are excellent vehicles for codelivering antigen and immune adjuvant and may find wider applications in biomedical fields.Īntigen delivery cellular immunity cytotoxic T lymphocyte metal−organic framework reduction-responsive.Kubernetes is emerging as one of the best control planes in the context of modern applications and infrastructure. Moreover, the increased frequencies of effector memory T cells inspired by the delivery system indicate that it can induce a potent immune memory response. By feat of the reductively controllable release of OVA and the promoting function of CpG, the delivery system can elicit strong cellular immunity and CTL response in mice. In vitro cellular tests show that the MOF nanoparticles can not only greatly improve the uptake of OVA by the antigen-presenting cells but also smartly deliver both OVA and CpG into the same cell. In this study, we use metal-organic framework (MOF) MIL-101-Fe-NH 2 nanoparticles as carriers to fabricate an innovative reduction-responsive antigen delivery system for cotransporting the antigen model ovalbumin (OVA) and an immune adjuvant, unmethylated cytosine-phosphate-guanine (CpG) oligonucleotide. Nevertheless, its applications are still far from practicality because of some limitations such as high cost, non-biocompatibility, non-biodegradability, and the inefficient stimulation of cytotoxic T lymphocyte (CTL) response. Utilizing nanoparticles to deliver subunit vaccines can be viewed as a promising strategy for enhancing the immune response, especially with regard to cellular immunity to fight against infectious viruses and malignant cancer.
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